Hinxton Training Event
When
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Short description:
In this training school/workshop the curation of DNA binding transcription factors (dbTF) is central. Case examples of dbTFs will be discussed and assigned to different curators to compare how they are able to use descriptions in a paper for annotation. The experiences will be used to fine-tune a dbTF curation guidelines document that was drafted by WG2 members.
Local organiser(s):
- Ruth Lovering
- Pascale Gaudet
Agenda:
| Monday 27th April | |
| Presentation 1 | 10am Ruth introduction with brief Q&A session |
| Presentation 2 | 10:20 am Pascale present transcription ontology revisions, with Q&A session |
| Presentation 3 | 10:40 am Pascale present GO annotation guidelines, with Q&A session |
| Breakout 1 | 11am paper 1: dbTF provided for everyone to curate based on guidelines, adding their annotations to a simple spreadsheet for comparison |
| Paper 1 slide | |
| 12 noon add your annotations to the Annotations Paper 1 tab: Ruth/Pascale to collate/review the information | |
| Discussion, presentation 4 (paper 1) | 1 pm discussion of annotations and Q&A, revision of guidelines as required |
| Breakout 2 | 2pm paper 2: dbTF + coTF provided for everyone to curate |
| Paper 2 slide | |
| 4pm return the annotations to Ruth/Pascale to collate the information | |
| Tuesday 28th April | |
| Discussion, presentation 4 (paper 1) | 10am continue paper 1 discussion : review revisions to presentation and new guidelines |
| Discussion, presentation 5 (paper 2) | 11am discussion of annotations submitted Monday 4pm and Q&A, revision of guidelines as required |
| Presentation 6 | 11:45? Ruth introduce the dbTFs gene list |
| Human genes scored according to presence in 9 dbTF lists (see presentation above for more information). | |
| Breakout 3 | 12 noon review proteins appear to be wrongly associate with dbTF GO terms |
| Discussion | 2 pm discussion of annotations and Q&A, revision of guidelines as required |
| 3pm Review of annotations of dbTF and coTFs associated with the 'transcription' BP terms (ie child terms) rather than 'regulation of transcription' BP terms | |
| 5pm Ruth/Pascale to collate the information | |
| Wednesday 29th April | |
| Discussion | 10am brief discussion of rules based on annotations submitted paper 2 and Q&A, revision of guidelines as required |
| 10:20 am discussion of review of dual annotations to the transcription and regulation process terms, Q&A, revision of guidelines as required | |
| 11:25 am break for 5 min | |
| Breakout 4 | 11:30 Breakout 4 Review 3 genes annotated to both DNA binding transcription factor AND transcription co-regulator activity |
| Discussion | 1pm discussion of annotations and Q&A, revision of guidelines as required |
| Presentation 7 | 2pm Colin to present coregulators |
| Presentation 8 | 3:00 pm summary of workshop and future plans |
| 4pm close meeting | |